A very fast, efficient, fully automated database search algorithm has been implemented as the open source R-package dnamatch2 (download R-package below). It carries out both "crime-stain-against-crime-stain" and "reference-against-crime-stain" comparisons, where the stains can be partial mixture profiles with allele drop-out.

For illustration, see conference paper "dnamatch2: An open source software to carry out large scale database searches
of mixtures using qualitative and quantitative models."